منابع مشابه
Peristalsis regulation by tachykinin NK1 receptors in the rabbit isolated distal colon.
In the gastrointestinal tract, tachykinin NK1 receptors are widely distributed in a number of neuronal and nonneuronal cells involved in the control of gut motor activity. In particular, in the rabbit isolated distal colon, which is a suitable model system to investigate the contribution of tachykinins as noncholinergic excitatory transmitters, the influence of NK1 receptors in the regulation o...
متن کاملNeural mechanisms of peristalsis in the isolated rabbit distal colon: a neuromechanical loop hypothesis
Propulsive contractions of circular muscle are largely responsible for the movements of content along the digestive tract. Mechanical and electrophysiological recordings of isolated colonic circular muscle have demonstrated that localized distension activates ascending and descending interneuronal pathways, evoking contraction orally and relaxation anally. These polarized enteric reflex pathway...
متن کاملMacromolecular transport across the rabbit proximal and distal colon.
BACKGROUND Although many studies have investigated macromolecular uptake in the stomach and small intestine, little is known about macromolecular uptake in the colon. AIMS To investigate the mechanisms involved in the transport of large antigenically intact macromolecules across the proximal and distal colonic epithelium in the rabbit. METHODS The mucosal to serosal movement of bovine serum...
متن کاملMass peristalsis in the human colon after contact with oxyphenisatin.
Colonic motility studies using time-lapse cinefluorography and intraluminal pressure recording before and after the introduction per rectum of a mixture of barium sulphate and oxyphenisatin solution show the different forms of movement of the colonic contents. Oxyphenisatin was found to be a selective actuator of a form of progressive mass propulsion indistinguishable from spontaneous mass peri...
متن کاملContribution of NK(2) tachykinin receptors to propulsion in the rabbit distal colon.
The role of the tachykinin neurokinin (NK)(2) receptors on rabbit distal colon propulsion was investigated by using two selective NK(2)-receptor antagonists, MEN-10627 and SR-48968. Experiments on colonic circular muscle strips showed that contractile responses to [beta-Ala(8)]NKA-(4-10) (1 nM-1 microM), a selective NK(2)-receptor agonist, were competitively antagonized by MEN-10627 (1-100 nM),...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1972
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1972.sp009693